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Pharmaceutical name: Human Growth hormone
Active Life: Varies by injection method
Average Dose: Men 3 - 7 i.u. total daily
Water Retention: Rare
Liver Toxic: No
Human Growth Hormone is a proteinaceous hormone made up of a chain of 191 amino acids and is produced by the pituitary gland. It is responsible for the protein deposition, growth of tissues, and the breakdown of subcutaneous fat stores. Human Growth Hormone is produced in its highest levels during adolescence, as should be no surprise since this is when the majority of a person's body growth occurs. In adulthood, growth hormone still circulates in the body but at much lower levels. The primary medical purpose for administration of human growth hormone is for those that suffer from a deficiency of the hormone during their adolescence so that normal growth can occur. However in recent years the popularity of HGH has surged as a means to treat age-related degenerative conditions, as well as other so-called "anti-aging" therapies.
HGH first became available in the 1980's. At first it was extracted from the pituitary glands of cadavers. This practice was discontinued however when it was determined that administration of the hormone that was collected this way was linked to the spread of a fatal brain disease. All of the human growth hormone that is now produced is synthetic.
In terms of the use of HGH for strength athletes and bodybuilders, the effects are two fold. First, it has been demonstrated that consistent administration of Hygetropin (HGH) can help to promote loss of body fat. In part this is due to the ability of the compound to cause cells in the body to increase the rate with which they utilize fats while also decreasing the rate that carbohydrates are used. This fat loss is achieved because of the ability of Growth Hormone to stimulate triglyceride hydrolysis in adipose tissue as well.
In conjunction with this, Human Growth Hormone helps to promote the movement of amino acids through cell membranes. This, along with the fact that growth hormone promotes the growth of the cells in the body and increases the rate at which these cells divide and multiple, obviously indicates that it is also capable of enhancing anabolism if used at appropriate doses.
Many users also have an interest in using HGH for the ability of the compound to help heal existing injuries and prevent new ones from occurring. There is some evidence that Growth Hormone can help to promote the production of new and regeneration of damaged cartilage when used in conjunction with insulin-like growth factor. It is actually the insulin-like growth factor that stimulates the production of cartilage. Insulin-like growth factor is released from the liver in response to circulating Growth Hormone.
It has also been demonstrated that Growth Hormone has positive effects on erythropoeisis, i.e. the manufacture of red blood cells. This effect should help to improve the endurance of an athlete and may also help to promote anabolism. To the degree with which this effect will occur in users varies quite widely, but all users should show some improvement.
As with no other doping drug, Growth Hormones are still surrounded by an aura of mystery. Some call it a wonder drug which causes gigantic strength and muscle gains in the shortest time. Others consider it completely useless in improving sports performance and argue that it only promotes the growth process in children with an early stunting of growth. Some are of the opinion that Growth Hormones in adults cause severe bone deformities in the form of overgrowth of the lower jaw and extremities. And, generally speaking, which Growth Hormones should one take the human form, the synthetically manufactured version, recombined or genetically produced form and in which dosage? All this controversy about growth hormones is so complex that the reader must have some basic information in order to understand them. The Growth Hormones is a polypeptide hormone consisting of 191 amino acids. In humans it is produced in the hypophysis and released if there are the right stimuli (e.g. training, sleep, stress, low blood sugar level). It is now important to understand that the freed Growth Hormone itself has no direct effect but only stimulates the liver to produce and release insulin-like growth factors and somatomedins. These growth factors are then the ones that cause various effects on the body. The problem, however, is that the liver is only capable of producing a limited amount of these substances so that the effect is limited. If Growth Hormones are injected they only stimulate the liver to produce and release these substances and thus, as already mentioned, have no direct effect.
HOW DOES IT WORKS?
Growth Hormone is, unlike most hormones used by bodybuilders, not a steroid hormone, but a proteinaceous hormone made up of a chain of 191 amino acids. All animals have growth hormone, but each seems to be specific to the species. HGH was first isolated in the late 70's and early 80's as a biological form. The hormone was literally extracted from the pituitary of deceased individuals. As with anything extracted from carcasses this imposed a serious risk of contracting the Kreutzfeld-Jacob disease (since the late 90's best known as mad cow disease), a normally rare neural infliction that makes you spastic and can cause death over a period of no more than two weeks. Not exactly appealing. There also wasn't, understandably, much demand for such a compound on the black market. Late 80's early 90's geneticists succeeded in manufacturing a genetic form of HGH however, through a very complicated technique using mice genes and what have you not (I'm not a geneticist, don't ask me). This also seriously upped the price of the compound.
But around that time, mainly due to this safer form, some top-level athletes were taking an interest. With increasing drug tests making the most effective anabolics forbidden territory, a pharmaceutical race to find replacement compounds that could not be detected had begun. And since then several athletes have and are still using HGH. It's a very mythical compound, since professionals will use it in high doses and make obvious improvements, yet most recreational users seeking to try it have to settle for lower doses and get little if anything out of it in terms of lean muscle mass increases. Along with several human studies that clearly document that HGH administration offers us no benefit in this aspect, it makes one wonder. Its terribly expensive and most people seem to get nothing out of it. So is it really worth it when extremely effective steroids can be bought for the proverbial nickel and dime? I don't think so, but I'll get back to that later.
Human Growth Hormone is primarily secreted in rhythmic pulses during sleep. This occurs by the mechanism of Growth Hormone Releasing Hormone and Somatostatin being released in an alternating fashion. For the most part users will want to mimic the natural release of growth hormone, while also not disrupting the body's natural production of the hormone. This is often a delicate balance.
In terms of a dosing schedule for the compound, there is some controversy as to the best method for fat loss/anabolism. It is thought by many that daily dosing is of primary importance when using Hygetropin due to the extremely short active life of the drug. Blood concentrations of the hormone reach their peak within two to six hours of the injection, with the half life being only twenty to thirty minutes. This of course makes it impossible to maintain stable blood levels of the compound.
However a stable level of the hormone is seemingly unnecessary as this does not occur naturally when the body produces the hormone. In fact there is some research that indicates that administration of the hormone every other day, instead of injections every day, may result in a more efficient use of the hormone. In a study using children ranging in ages of two to four, it was demonstrated that administration of the compound every other day, as opposed to every day, resulted in more growth in the children giving this dosing schedule. One theory as to why this may occur is that injections every other day may simulate the natural pulsile frequency of Growth Hormone secretion. This would also allow the Growth Hormone receptors in the body recover from the surge of Growth Hormone that would be circulating and then be better able to make use of the next dose that is administered the next day.
The only problem with the above theory is that it has never been tested in terms of its effect on muscle growth and/or fat loss, only in the height growth in extremely young children. For the most part strength athletes and bodybuilders have administered growth hormone every day and have achieved good results. This method would seemingly provide a user with a consistent wave of Growth Hormone throughout their cycle and allow the body to utilize it rather efficiently.
Another common practice among users is to run Hygetropin for five days and then take one or two days off, or some other similar schedule. This would seemingly be "splitting the difference" between the two dosing schedules outlined above, but there is no research to indicate that it is of any significant benefit either way.
As for the time of day a user should inject Growth Hormone, it would be least disruptive to the natural release of the hormone to administer it sometime early in the day. If a user were to inject it close to when they were going to sleep, this would surely negate any natural release of HGH, something that a user would obviously want to avoid. There is no standard to which most adhere to when deciding how close to going to sleep that they will administer Growth Hormone, however mid-afternoon should be early enough that it does not interfere with the natural release of the hormone during sleep.
In terms of dosages needed to see specific results, there is primarily only anecdotal evidence to be relied upon when it comes to fat loss and an anabolic response. The relevant research does not discuss these effects in any great scope. However, most users have indicated that doses of approximately two to six international units per day in men will usually produce a noticeable loss of body fat in most users. In terms of getting an anabolic response, the experience of users vary considerably. For the most part it can be concluded that most users will need to administer larger doses than needed to experience fat loss if they wish to see a noticeable anabolic response from Growth Hormone. How much more varies from individual to individual. There are some users who have indicated that using extremely large doses of the hormone has resulted in dramatic gains in muscle mass, but often these doses are cost prohibitive for most. Individuals will likely have to experiment themselves to find a level that they are comfortable with, as well as what they can afford.
As for the duration of a cycle of HGH, it is believed by many that the compound must be administered for a minimum of 20 to 30 weeks to see results. The action of the compound is slow acting and therefore lengthy cycles are needed. However due to its relative safety it can be run for several months, and even years, with little to no negative results. Of course this is dependent on the user and his or her individual reaction to the compound, along with the doses that they are using.
Humanotrope can be administered using either intra-muscular or subcutaneous injections. There is no difference in the absorption of the compound.
No type of post-cycle therapy is necessary when discontinuing Hygetropin as it should continue to be produced naturally by the body of the user. The negative feedback loop that indicates to the body that there is enough of the hormone circulating is related to insulin-like growth factor. Specifically, when insulin-like growth factor is secreted by the liver a signal is sent to the pituitary gland and hypothalamus to cease the production of Growth Hormone.
The undesired effect of Growth Hormones, the so-called side effects, are also a very interesting and hotly-discussed issue. Above all it must be said: HGH has none of the typical side effects of anabolic/androgenic steroids including reduced endogenous testosterone production, acne, hair loss, aggressiveness, elevated estrogen level, virilization symptoms in women, and increased water and salt retention. The main side effects that are possible with Growth Hormone are an abnormally small concentration of glucose in the blood (hypoglycemia) and an inadequate thyroid function. In some cases antibodies against Growth Hormones are developed but are clinically irrelevant. What about the horror stories about acromegaly, bone deformation, heart enlargement, organ conditions, gigantism, and early death? In order to answer this question a clear differentiation must be made between humans before and after puberty. The growth plates in a person continue to grow in length until puberty. After puberty neither an endogenous hypersection of Growth Hormones nor an excessive exogenous supply of HGH can cause additional growth in the length of the bones. Abnormal size (gigantism) initially goes hand in hand with remarkable body strength and muscular hardness in the afflicted; later, if left untreated, it ends in weakness and death. Again, this is only possible in pre-pubescent humans who also suffer from an inadequate gonadal function (hypogonadism). Humans who suffer from an endogenous hypersecrehon after puberty and whose normal growth is completed can also suffer from acromegaly. Bones become wider but not longer. There is a progressive growth in the hands and feet and enlargement of features due to the growth of the lower jaw and nose.